ADVANCED SYNTHESIS IN ORGANIC CHEMISTRY PART. A
Deep knowledge of basic Organic Chemistry, particularly with respect to aliphatic and aromatic reactivity
The course has the aim to provide students with advanced knowledge of Organic Synthesis including the most innovative methods for the formation of carbon-carbon and carbon-heteroatom bonds. Synthesis and preparation of highly complex molecules will be illustrated and studied.
The organic synthesis today
Olefination reactions
Metathesis reactions
Approach to total synthesis (concepts and examples) of natural products and bioactive compounds.
New methodologies and new reagents in Organic Synthesis.
Review and literature on new discoveries and applications in organic synthesis
Examples of total synthesis of a molecule with different approaches (Total Synthesis of Lysergic Acid)
Literature reports and papers will be object of study and analysis during the lectures. Slides and didactic support will be delivered and here there are only few examples of consultation textbooks.
F.A.Carey , R.J.Sundberg Advanced Organic Chemistry Part B (Reactions and Synthesis) Springer Science 2007, 5th Edition
S. Warren, P. Wyatt - Organic Synthesis: the Disconnection Approach
S. Warren, P. Wyatt - Organic Synthesis: Strategy and Control
E. J. Corey, Xue-Min Cheng - The Logic of Chemical Synthesis
K.C. Nicolaou, E.J. Sorensen - Classics in Total Synthesis
K.C. Nicolaou, S.A. Snyder - Classics in Total Synthesis II
K.C. Nicolaou, J.S. Chen - Classics in Total Synthesis III
T. Hudlicky, J.W. Reed - The Way of Synthesis
K.C. Nicolaou, T. Montagnon - Molecules that changed the world
E.J. Corey, L. Kurti, B. Czako - Molecules and Medicine
M.B. Smith - Organic Synthesis