ADVANCED ORGANIC CHEMISTRY
Knowledge of fundamental concepts of Organic Chemistry
The course has the following objectives
-to give the security basics that must be follow to work in an Organic Laboratory
-to analyze the most important operations typically performed during an organic synthesis.
-to present the most common purification techniques of organic compounds
-to illustrate the most important methodologies employed for the characterization and identification of organic compounds
-to show the basics necessary to edit scientific reports inherent to the procedures and the results of laboratory experiences
COURSE PROGRAM
Security rules in laboratory
Solvent typology and their characteristics
Purification and isolation methods: filtration, extraction, distillation, crystallization, column chromatography
Characterization methods: boiling point, melting point, thin layer chromatography (TLC). IR spectroscopy. Introduction to NMR spectroscopy
LABORATORY EXPERIENCES
Separation of a mixture of compounds
Oxidation of a secondary alcohol to a ketone
Reduction of a ketone to an alcohol
Aldolic condensation
Synthesis of a dihydropyrazole
Synthesis of indigo and cotton dyeing
Nitration reaction
Reaction through a diazonium salt
Resolution of a racemic amine
Synthesis of a polyamide
Frontal lections and laboratory experieces
- D.L. Pavia, G.M. Lampman, G.S. Kriz: Il Laboratorio di Chimica Organica, Edizioni Sorbona, MI, 1994.
- M. D’Ischia: La Chimica Organica in Laboratorio, Piccin, Padova, 2002;
Both the experiments performed by the students in the Laboratory and the related reports will be evaluated. The resulting evaluation will contribute to the final mark of the exam of Organic II (module A and B). In addition, at least one question inherent to the program carried out and laboratory activies will be included in the written exam of Module B