CELLULAR AND MOLECULAR PHARMACOLOGY
General notions regarding the pharmacodynamics concerning in particular the mechanisms of drug action and the consequence for the therapeutic purposes of such mechanisms; will deepen the mechanisms of receptor action, ion channels, enzymes and all other mechanisms; their relevance for the dose-response relationship and the measure of the pharmacological effect, the evaluation of efficacy and potency, and the pharmacodynamic interactions will be considered.
Receptor mechanisms of drug action. Receptor theories. Stimulus-response relationship and signal transduction mechanisms. Drug / receptor interaction: affinity, efficacy and intrinsic activity. Receptor states. Receptor regulation.
Cellular and molecular pharmacology of receptor systems: adrenergic, cholinergic, dopaminergic, GABAergic, serotoninergic, glutamatergic, histaminergic, opioid.
Cellular and molecular pharmacology of ion channels: Na +, K +, Ca2 +, Cl-.
Cellular and molecular pharmacology of enzyme systems, with examples.
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- Rang HP, Dale MM, Ritter JM Farmacologia, Casa Editrice Ambrosiana, Milano
- Golan DE et al. Principi di Farmacologia – Le basi fisiopatologiche delle malattie, Casa Editrice Ambrosiana, Milano
- Katzung BG Farmacologia generale e clinica Piccin, Padova
- Howland MD, Mycek MJ Le basi della farmacologia, Zanichelli, Bologna
- Birkett DJ Elementi di farmacocinetica, Piccin, Padova
Frontal lesson with the help of slidea and scientific literature
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