PART I. METHODOLOGY IN EPIDEMIOLOGY
1.Principal epidemiological study: observational study, cross-sectional study, case-control study, cohort study, ecological study
2.Measure of frequency: prevalence, incidence, incidence rate
3.Measure of association: Relative risk, odds ratio, absolute risk, attributable risk

PART II. STUDY VALIDITY
1.Bias e confounding: selection bias, information bias, confounding
2.Interaction and mediation of effect
3.Methods for confounding control: sample identification, data collection, randomization, restriction, matching, stratified and multivariate analysis.

PART III. INFORMATIVE SOURCES OF DATA
1.Registry: cancer registry, stroke registry.

PARTE IV. EVALUATION OF EFFICACY
1.Clinical trials: design, equivalence trial, ethical aspect
2.Concept of statistical inference: confidence intervals, p value, power and sample size of the study.
3.The reviews: bibliographic search, metanalysis, systematic review