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SCIENZE CLINICHE 2

Degree course: 
Corso di First cycle degree in Biomedical Laboratory techniques
Academic year when starting the degree: 
2016/2017
Year: 
2
Academic year in which the course will be held: 
2017/2018
Credits: 
5
Period: 
Second semester
Standard lectures hours: 
60
Requirements: 

ALLERGOLOGY AND CLINICAL IMMUNOLOGY
No pre-requisites for this course are required.

Final Examination: 
Orale

ALLERGOLOGY AND CLINICAL IMMUNOLOGY
The exam will consist of an oral exam, two questions, in which the student will be asked to demonstrate the knowledge about the program he is doing. The objective of the exam is to check the level of achievement of the above-mentioned training objectives, ie to assess the student's level of knowledge about the functioning of the various cells of the immune system, its molecules, allergy and other immune-mediated pathologies and immune system modulation processes. The outcome of the exam will be with Suitability.
In particular, the aim of the exam is to evaluate the student's skills in relation to:
1. Basic knowledge of the innate and adaptive immune system, understanding of cellular and molecular mechanisms of sensitization and immune activation in response to the recognition of an innocuous foreign substance in the allergy or pathogen and the mechanisms of interaction and cooperation between the immune system innate and adaptive;
2. Understanding and deepening the dynamics of allergology and clinical immunology, and the processes of immune reactions in HIV infection, immunodeficiency, autoimmunity, tumor response, transplants and vaccines.

Assessment: 
Giudizio Finale

ALLERGOLOGY AND CLINICAL IMMUNOLOGY
The course provides the principles of allergology and clinical immunology, in particular of innate and acquired immunity, their dynamics and their functioning in health and illness.
The student will have to demonstrate:
1) Have learned about the functioning of the various cell types, their interactions and the basic molecules of the immune system;
2) Have developed understanding and description skills of the various mechanisms of the allergy and the various types of hypersensitivity as well as immune system modulation processes in vaccines and immunotherapy;
3) to be able, through a critical and concise discussion of the topic of interest, to deepen such knowledge autonomously in the application aspects of that science;
4) to know how to conceive and support theoretical and practical arguments in order to solve specific problems of allergology and immunology.

ALLERGOLOGY AND CLINICAL IMMUNOLOGY
The front lessons will address the following topics:
General characteristics of the immune system. Internal innate defenses. Molecules and cells of innate immunity. Acute inflammatory reaction, proinflammatory cytokines and acute phase proteins (4h).
Antigen recognition by T lymphocytes and lymphocytes B. Formation of antigen receptors on lymphocytes. Presentation of the antigen to lymphocytes T. The Higher Complexity of Istocompatibility and its functions (4h).
Lymphocyte activation mechanisms. Positive and negative selection in thymus. The response of T cells (4h).
The humoral immune response. Various types and functions of antibodies. Dynamics of acquired immunity. Immune memory (4h).
Allergies and allergic diseases. The genetic and environmental bases of the allergy. Hypersensitivity (4h).
Deficiencies of host defense mechanisms. Immune deficiency diseases and HIV. Autoimmunity. Transplantation. Immune surveillance of tumors. Various types of vaccines (4h).

ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Janeway Immunobiology (PICCIN, 8th Edition, 2014).
Slide lessons: downloadable from the University's E-learning site.

ALLERGOLOGY AND CLINICAL IMMUNOLOGY
The course consists of 24 hours of frontal lessons (2 CFUs). These lessons will be supported by power point slides projection.

ALLERGOLOGY AND CLINICAL IMMUNOLOGY
The lecturer is available for further information or clarification on topics discussed for individual students or groups of students. He will receive students, after making an appointment by e-mail (lorenzo.mortara@uninsubria.it), at the Immunology and General Pathology Laboratory (1st floor), former Colonia Agricola, via Monte Generoso 71 (int. 4), Varese.

Modules