BACI DENISA
Role
Titolare di assegno di ricerca
Organization unit
Sito web:
Arguments
Cell-to-cell communication by extracellular vesicles and microRNAs
Tumor microenvironment, inflammation, natural killer cells, angiogenesis.
Human organoids, 3D-Bioprinting for drug testing and disease modeling.
Cancer biology, cardiotoxicity associated with anti-neoplastic drugs.
Stem cell-based therapies and biomaterials for cardiovascular tissue engineering.
Research
Research projects:
Effects of Non-small cell lung cancer (NSCLC)-derived exosomes and their cargo, exomiRNAS, on NK cell polarization.
The role of RNASET2 in modulating the innate immune system in prostate cancer and multiple myeloma.
Publications
- Baci D. Chirivi M, Pace V, Maiullari F, Milan M, Rampin A, Somma P, Presutti D, Garavelli S, Bruno A, Cannata C, Lanzuolo C, Gargioli C, Rizzi R and Bearzi C. Extracellular Vesicles from skeletal muscle cells efficiently promote myogenesis in induced pluripotent stem cells. Manuscript ID: cells-793504 Under revision
- Baci D, Bosi A, Gallazzi M, Rizzi M , Noonan DM, Poggi A, Bruno A, Mortara L. The ovarian cancer tumor- immune microenvironment (TIME) as target for therapy: a focus on innate immunity cells as therapeutic effectors. International Journal of Molecular Sciences. Manuscript ID: ijms-750925: Review. Accepted
- Bruno V, Corrado G, Baci D, Chiofalo B, Carosi MA, Ronchetti L, Piccione E, Albini A, Noonan DM, Piaggio G, Vizza E. Endometrial Cancer Immune Escape Mechanisms: Let Us Learn From the Fetal-Maternal Interface. Front Oncol. 2020 Mar 12;10:156. doi: 10.3389/fonc.2020.00156.
- Acquati F, Mortara L, De Vito A, Baci D, Albini A, Cippitelli M, Taramelli R, Noonan DM. Innate Immune Response Regulation by the Human RNASET2 Tumor Suppressor Gene. Front Immunol. 2019 Nov 5;10:2587. doi: 10.3389/fimmu.2019.02587.
- Baci D, Bruno A, Cascini C, Gallazzi M, Finzi G, Sessa F, Mortara F, Albini A, Douglas Noonan DM. Acetyl-L- Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies. J Exp Clin Cancer Res. 2019 Nov 12;38(1):464. doi: 10.1186/s13046-019-1461-z.
- Bruno A, Mortara L, Baci D, Noonan DM, Albini A. Myeloid Derived Suppressor Cells Interactions with Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression. Front Immunol. 2019 Apr 18;10:771. doi:10.3389/fimmu.2019.00771.
- Bassani B*, Baci D*, Gallazzi M, Poggi A, Bruno A, Mortara L. Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects. Cancers (Basel). 2019 Apr 1;11(4). pii: E461. doi: 10.3390/cancers11040461.
- Baci D, Gallazzi M, Cascini C, Tramacere M, De Stefano D, Bruno A, Noonan DM, Albini A. Downregulation of Pro-Inflammatory and Pro-Angiogenic Pathways in Prostate Cancer Cells by a Polyphenol-Rich Extract from Olive Mill Wastewater. Int J Mol Sci. 2019 Jan 14;20(2). pii: E307. doi: 10.3390/ijms20020307.
- Maiullari F, Costantini M, Milan M, Pace V, Chirivì M, Maiullari S, Rainer A, Baci D, Marei H, Seliktar D, Gargioli C, Bearzi C. A multi-cellular 3D bioprinting approach for vascularized heart tissue engineering based on HUVECs and iPSC- derived cardiomyocytes. Sci Rep. 2018 Sep 10;8(1):13532. doi:10.1038/s41598-018-31848-x. PubMed PMID: 30201959.
- Baci D, Bruno A, Bassani B, Tramacere M, Mortara L, Albini A, Noonan DM.Acetyl-l-carnitine is an anti- angiogenic agent targeting the VEGFR2 and CXCR4pathways. Cancer Lett. 2018 Aug 10; 429:100-116. doi: 10.1016/j.canlet.2018.04.018.
- Parisi L, Gini E, Baci D, Tremolati M, Fanuli M, Bassani B, Farronato G, BrunoA, Mortara L. Macrophage Polarization in Chronic Inflammatory Diseases: Killersor Builders? J Immunol Res. 2018 Jan 14; 2018:8917804. doi: 10.1155/2018/8917804.
- Milan M, Pace V, Maiullari F, Chirivì M, Baci D, Maiullari S, Madaro L, Maccari S, Stati T, Marano G, Frati G, Puri PL, De Falco E, Bearzi C, Rizzi R. Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation. Cell Death Dis. 2018 Jan 25;9(2):108. doi: 10.1038/s41419-017-0174-5.
- D'Uva G, Baci D, Albini A, Noonan DM. Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment. Cancer Treat Rev. 2017 Nov 11; 63:1-18. doi: 10.1016/j.ctrv.2017.10.013.
- Albini A, Bassani B, Baci D, Dallaglio K, Gallazzi M, Corradino P, Bruno A, Noonan DM. Nutraceuticals and "repurposed" drugs of phytochemical origin in prevention and interception of chronic degenerative disease and cancer. Curr Med Chem. 2017 Sep 20. doi: 10.2174/0929867324666170920144130.
- Nuti E, Bassani B, Camodeca C, Rosalia L, Cantelmo A, Gallo C, Baci D, Bruno A, Orlandini E, Nencetti S, Noonan DM, Albini A, Rossello A. Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues. Eur J Med Chem. 2017 Sep 29; 138:890-899. doi: 10.1016/j.ejmech.2017.07.024. Epub 2017 Jul 17.
- Deroost K, Lays N, Pham TT, Baci D, Van den Eynde K, Komuta M, Prato M, Roskams T, Schwarzer E, Opdenakker G, Van den Steen PE. Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.PLoS One. 2014 Nov 24; 9(11): e113519. doi: 10.1371.
- Bearzi C, Gargioli C, Baci D, Fortunato O, Shapira-Schweitzer K, Kossover O, Latronico MV, Seliktar D, Condorelli G, Rizzi R. PlGF-MMP9-engineered iPS cells supported on a PEG-fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium. Cell Death Dis. 2014 Feb 13; 5: e1053. doi:10.1038/cddis.2014.12.
- Zanini C, Bruno S, Mandili G, Baci D, Cerutti F, Cenacchi G, Izzi L, Camussi G, Forni M. Diffrentiation of mesenchymal stem cells derived from pancreatic islets and bone marrow into islet-like cell phenotype. PLoS One. 2011; 6(12): e28175. doi: 10.1371/journal.pone.0028175. Epub 2011 Dec 16.
- Zanini C, Mandili G, Bertin D, Cerutti F, Baci D, Leone M, Morra I, di Montezemolo Cordero L, Forni M. Analysis of different medulloblastoma histotypes by two-dimensional gel and MALDI-TOF. Childs Nerv Syst. 2011 Dec; 27(12):2077-85. doi: 10.1007/s00381-011-1515-9. Epub 2011 Jun 30.
- Barrera V, Skorokhod OA, Baci D, Gremo G, Arese P, Schwarzer E. Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action. Blood. 2011 May 26; 117(21):5674-82. doi: 10.1182/blood-2010-10-312413. Epub 2011 Apr 1.
- Zanini C, Mandili G, Baci D, Leone M, Morra I, Forni M. Proteomic Profile Modification of Anaplastic Medulloblastoma After in-Vivo Radiotherapy: a Case Study. Journal of Cancer Therapy in May 24, 2010. Vol.2, No.1.
- Rainero I, Rubino E, Cappa G, Rota E, Valfrè W, Ferrero P, Fenoglio P, Baci D, D'Amico G, Vaula G, Gallone S, Pinessi L. Pro-inflammatory cytokine genes influence the clinical features of frontotemporal lobar degeneration. Dement GeriatrCognDisord. 2009; 27(6):543-7. doi: 10.1159/000225962. Epub 2009 Jun 23.